Types of Insulin | |||
Insulin type (trade name) | Onset | Peak | Duration |
Bolus (preprandial or mealtime) insulins | |||
Rapid-acting insulin analogues (clear)
|
9-20min 10-15min 10-15min 4min |
1-1.5h 1-1.5h 1-2h 0.5-1.5h |
3-5h 3.5-5h 3-4.75h 3-5h |
Short-acting insulins (clear)
|
30min 15min |
2-3h 4-8h |
6.5h 17-24h |
Basal insulins | |||
Intermediate-acting (cloudy)
|
1-3h |
5-8h |
Up to 18h |
Long-acting insulin (clear)
|
90min |
Not applicable |
U-100 glardine 24h, detemir 16-24h U-300 glargine >30h degludec 42h |
Premixed insulins | |||
Premixed regular insulin –NPH (cloudy)
|
A single vial or cartridge contains a fixed ratio of insulin |
||
Premixed insulin analogues (cloudy)
|
(% of rapid-acting or short-acting insulin to % of intermediate-acting insulin) |
||
Data represents estimations derived from pooled data analysis using various experimental conditions. There is significant inter- and intra-individual variation in pharmacokinetics and pharmacodynamics depending on a variety of clinical factors, including dose. Physicians should refer to the most current edition of Compendium of Pharmaceuticals and Specialties (Canadian Pharmacists Association; Ottawa, Ontario, Canada) and products monographs for detailed information. |
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